Reversal of Graft-Versus-Host Disease with Infusion of Stored Autologous Bone Marrow Cells Following Combined Liver-Bone Marrow Allotransplantation in Man.

Graft-versus-host reaction was first described following splenocyte transplantationl and was correctly attributed to recognition of the host by immunologically competent cells of the graft. Soon, the same phenomenon was recognized in recipients of organs that are rich in lymphoid tissue2 and was demonstrated after parent to offspring Fl hybrid intestinal transplantation in rats. 3 An increasing frequency of graft-versus-host-disease (GVHD) has been observed after transplantation of other organs, including the human liver4 . l2 In this report, we describe reversal of GVHD in a recipient of a combined liver-bone marrow transplant by infusion of stored autologous bone marrow cells.